Please be original. I'm sick of everyone quoting Star Fox 64, Zero Wing & Fawful...
Anyways, here are mine:
Doc Waruyama: "water can DESTROY Pulseman! hahahaha!."
(If you've played Pulseman, you'll know why this is such an awesome quote.)
"it's super effective!"
"yuck! shouldn't have looked!"
(from the JP version of Megaman X) Zero: X, I've finally discovered Sigma's stronghold! it's friggin HUGE!!
(^ I love how Zero kinda talks like a teenager. XD)