Everybody Hates Chris, I mean, the title alone gives it away. :P
Look Forward, Team Rocket!
Also I claim Piplup in the Claim a Pokemon thread =)
Fawlty Towers springs immediately to mind.
The Walking Dead. I mean, just when Rick thinks everything is alright, his wife and friend die. He's forced to kill his traitorous best friend, and is on the run from motherfucking zombies throughout the entire series. Then, two of his friends are held captive in a place called Woodbury. Even after freeing them, yet another one of his friends is captured. He also loses his mind about halfway through season 3. I think that Rick's got it pretty bad.
Long live the Confederacy!