Unova is the richest region, what with its large cities and extensive TR operations.
Ghetsis was doing a public service by removing a "Gropius" from the world.
Unovans are so xenophobic against Kantonians because the two of them have a bad history together.
Misty is over her crush on Ash and is now dating some random dude from Cerulean.
Kyurem has far more power than he appears.
Cynthia has ties to Team Galactic and fled Sinnoh and the authorities.
Zekrom was trolling Ash and made him lose to Trip because he thought it was funny.