You only need to read my account name to understand my opinion of generation one, but even I'm unsure of this.
Maybe in the future, far, far in the future, it'd be cool. Like, Gen 8 or something. But it's too soon at the minute. I agree with what other people have been saying though. I want to see a game where you start in Kanto, maybe somewhere different to Pallet town, and go through the whole place, 3-5 years after HG SS. Cinnabar would be being rebuilt, the radio would have much more influence, some of the Gym Leaders would maybe have changed, new antagonists etc. It would tie up the last remaining lose end about the Rockets too, about Giovanni's supposed suicide. After Kanto, you'd maybe be able to go through Johto again, too; it'd be interesting to see how it would affect game play if you did it the other way around. I think three regions in one game is too much, however GF would be stupid not to include the Sevii Islands.
In fact, I'd like to see a game based primarily on the Sevii Islands. There were originally going to be more than seven of them; perhaps this game would introduce more of them. It'd obviously be different to your average story line, with no Gyms etc, but maybe after you'd completed the main story, ou could visit Kanto.
Although I don't see Pokemon eneding any time soon, if it was going to end, another, good R/B remake would be nice just to close the franchise. Other than that, I think they'd have to wait a while to make one.